Sarcopenia & Muscle Loss
Objective muscle-strength endpoints for sarcopenia and age-related muscle loss protocols, with standardized isokinetic and isometric knee-extension testing across visits.
- Peak torque
- Isometric strength
- Longitudinal change
Isokinetic strength assessment
A Clinical Research Site With an In-House Biodex System 4 Pro
West Clinical Research is a dedicated, private clinical research site with locations in Morehead City and Greenville, North Carolina. Our on-site Biodex System 4 Pro isokinetic dynamometer, operated by staff physical therapists and athletic trainers, is ready for sarcopenia, muscle loss, obesity and weight-loss, sports medicine and orthopedic trials with strength endpoints.
Central IRB. Rapid study startup. A dedicated in-house recruitment team.
Capability snapshot
- Equipment
- Biodex System 4 Pro, on site
- Operators
- Staff physical therapists and athletic trainers
- Investigators
- Orthopedics, sports medicine, obesity, internal medicine and more
- IRB
- Central IRB, rapid startup
- Site type
- Dedicated private research site
- Locations
- Morehead City and Greenville, NC
- Testing modes
- 4
- Isokinetic, isometric, isotonic, passive
- Joints tested
- 6
- Knee, hip, ankle, shoulder, elbow, wrist
- Investigator specialties
- 6
- Practicing physicians
- Feasibility response
- 1 day
- Usually within one business day
01Study types
Clinical Trials We Are Set Up to Run on the Biodex
Isokinetic dynamometry gives a sponsor an objective, reproducible strength endpoint. We already have the equipment, the clinicians and the procedures in place, so a protocol with muscle-strength or functional outcomes can run entirely on site.
Obesity & Weight-Loss Trials
Strength and lean-mass preservation assessments for weight-management and metabolic studies, with obesity medicine investigators on staff.
- Lean-mass preservation
- Strength during weight loss
- Metabolic endpoints
General Strength Assessment
Baseline and follow-up strength testing for any protocol that needs a reproducible, quantitative measure of muscle function rather than a self-reported scale.
- Isokinetic
- Isometric
- Isotonic
Sports Medicine & Rehabilitation
Return-to-play, post-injury and post-surgical recovery protocols run by sports medicine physicians, orthopedic surgeons, physical therapists and athletic trainers.
- Bilateral deficit
- Agonist/antagonist ratio
- Rehab progression
Strength Training & Performance
Training-response and performance studies where isokinetic dynamometry is the primary or secondary strength outcome.
- Power
- Work
- Fatigue index
Any Protocol That Specifies a Biodex
If your protocol calls for isokinetic dynamometry, whether in orthopedics, osteoarthritis, neuromuscular disease, cachexia or musculoskeletal recovery, we can run it to the protocol’s testing procedure.
- Protocol-specified testing
- Musculoskeletal
- Neuromuscular
02The equipment
What the Biodex System 4 Pro Measures
The current-generation Biodex multi-joint isokinetic dynamometer quantifies muscle strength, power, work and endurance at controlled speeds and positions, so a change in a participant’s strength is measured rather than estimated.
Every test follows the protocol’s specified joint, mode, speeds, repetitions and warm-up, and the same trained operators run the assessment at each visit to keep variability down.
Testing Modes
- Isokinetic (concentric and eccentric)
- Isometric
- Isotonic
- Passive / continuous passive motion
Joints Tested
- Knee (extension / flexion)
- Hip
- Ankle
- Shoulder
- Elbow
- Wrist
Reported Outputs
- Peak torque and peak torque to body weight
- Total work and average power
- Time to peak torque
- Agonist / antagonist ratios
- Bilateral (side-to-side) deficit
- Work fatigue and endurance ratios
03The team
The Clinicians Behind the Machine
A dynamometer is only as good as the people running it. Our strength assessments are performed and interpreted by clinicians who use this equipment in practice, and our investigators are the specialists sponsors expect on a musculoskeletal or metabolic protocol.
Physical Therapists
Set up, position and test participants on the Biodex using standardized, protocol-specific procedures so strength data stays consistent from visit to visit.
Athletic Trainers
Support testing, warm-up and familiarization, and the sports medicine and rehabilitation protocols the site runs.
Orthopedic Surgeons
Investigators for orthopedic, post-surgical and musculoskeletal studies where strength recovery is an endpoint.
Sports Medicine Physicians
Investigators for sports medicine, rehabilitation, return-to-play and performance protocols.
Obesity and Internal Medicine Physicians
Investigators for weight-management and metabolic protocols, where strength and lean-mass preservation increasingly matter as endpoints.
04The site
A Dedicated Clinical Research Site
The Biodex is one piece of a site built for industry-sponsored trials. Research is our business, and the operations around the equipment are set up to start fast and enroll predictably.
Central IRB and Rapid Study Startup
We use central IRBs, so there is no local IRB queue between contract execution and first patient in. Feasibility, budget and regulatory run in parallel.
A Dedicated In-House Recruitment Team
Recruitment is a full-time function, not a side task for coordinators. Our team prescreens, schedules and follows up so enrollment is a plan, not a hope.
Research Is Our Business
Our team, equipment and clinic are dedicated to running clinical trials with our expert investigators. Our clinical research coordinators work only in research.
Expert Investigators
Our investigators are experts in their fields: practicing physicians in orthopedic surgery, sports medicine, psychiatry, obesity medicine, internal medicine, and family and emergency medicine.
Site Facts
- Study phases
- II, III, IV
- Strength assessment
- Biodex System 4 Pro, on site
- Site staff
- Principal investigators, sub-investigators, certified clinical research coordinators (CCRC), startup specialist, data entry, dedicated recruitment team, physical therapists, athletic trainers
- IRB
- Central IRB preferred
- Laboratory
- On-site draws, local and central lab
- Sample storage
- -80°C, -20°C, 2-8°C, ambient
- Drug storage
- Temperature-controlled and monitored, blinded and unblinded
- EDC experience
- Medidata Rave, Oracle Clinical, Veeva Vault, REDCap and others
Regulatory documents, investigator CVs and equipment calibration records are available on request.
05Questions
Frequently Asked Questions
Does West Clinical Research have a Biodex on site?
Yes. West Clinical Research has an in-house Biodex System 4 Pro isokinetic dynamometer at our research facility in Morehead City, North Carolina. Testing is performed on site by our trained physical therapists and athletic trainers.
What kinds of clinical trials can use the Biodex System 4 Pro?
We are set up for sarcopenia and muscle-loss studies, strength and lean-mass assessments in obesity and weight-loss trials, general strength assessments, sports medicine and rehabilitation protocols, strength-training and performance studies, and any protocol that specifies isokinetic, isometric or isotonic dynamometry.
Who performs the strength testing?
Trained physical therapists and athletic trainers on staff perform Biodex testing using standardized, protocol-specific procedures. Our investigators are experts in their fields: practicing physicians in orthopedic surgery, sports medicine, psychiatry, obesity medicine, internal medicine, and family and emergency medicine.
Is West Clinical Research a dedicated research site?
Yes. West Clinical Research is a dedicated, privately owned clinical research site focused on industry-sponsored trials. We use central IRBs, negotiate contracts and budgets directly, and have a full-time recruitment team, which keeps startup fast and enrollment predictable.
Do you use a central IRB?
Yes. We prefer central IRBs for rapid study startup, and we run feasibility, budget and regulatory work in parallel so a study can move from contract to first patient in quickly.
Where is the site and what population do you recruit from?
We have locations in Morehead City and Greenville, North Carolina, serving the Crystal Coast and Eastern North Carolina. The Morehead City office is at 4218-C Arendell Street. Our dedicated in-house recruitment team draws on a local patient database, community outreach and referring-clinician relationships across the region.
How do I request feasibility for a study with strength endpoints?
Use the inquiry form on this page or email info@westclinicalresearch.com with the protocol or indication and the strength assessments required. We typically respond with a feasibility answer and site documents within one business day.
06Feasibility
Placing a Study With Strength Endpoints?
Send us the protocol synopsis or the indication and the strength assessments it requires. We will come back with a feasibility response, investigator CVs and site documents.
Looking for the full site profile? For sponsors & CROs.